Molecular Genetic Analysis of an Endotoxin Nonresponder Mutant Cell Line
نویسندگان
چکیده
منابع مشابه
Molecular Genetic Analysis of an Endotoxin Nonresponder Mutant Cell Line
Somatic cell mutagenesis is a powerful tool for characterizing receptor systems. We reported previously two complementation groups of mutant cell lines derived from CD14-transfected Chinese hamster ovary--K1 fibroblasts defective in responses to bacterial endotoxin. Both classes of mutants expressed a normal gene product for Toll-like receptor (TLR)4, and fully responded to stimulation by tumor...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2001
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.194.1.79